Which Native American groups were impacted by Spanish expeditions?

The Karankawa and Caddo were impacted significantly by Spanish expeditions, as these two groups inhabited regions that Spanish explorers sought to conquer and settle. The Karankawa lived along the Gulf Coast, where early Spanish explorers, such as Alvar Núñez Cabeza de Vaca, made contact with them during the early 16th century. This led to various interactions, including trade and conflict, which had lasting effects on the Karankawa's traditional lifestyle.

The Caddo, located further inland in what is now East Texas, engaged with Spanish explorers and missionaries as they sought to expand their influence in the region. The Spanish mission system aimed to convert Indigenous peoples to Christianity, which directly affected the Caddo's cultural practices and societal structures.

In contrast, other groups listed do not share the same direct historical context with Spanish expeditions in Texas. The Apache and Comanche, while they did have encounters with the Spanish, became more prominent in northern or western Texas and did not experience early Spanish contact to the same extent as the Karankawa and Caddo. The Sioux and Iroquois are from the Great Plains and Northeast regions, respectively, and were not significantly involved with Spanish expeditions in Texas. Lastly, the